Integrated bioinformatics and mendelian randomization reveal a six-gene diagnostic signature and key role of CYP26B1 in sarcopenia

This study identified a highly reliable six-gene diagnostic signature for sarcopenia. Mendelian randomization established CYP26B1 as the sole causal factor, linking retinoic acid metabolism to disease etiology. This dual evidence provides a robust six-gene diagnostic model and a prioritized therapeutic target, elucidating immune-metabolic mechanisms of sarcopenia. These findings offer new avenues for early diagnosis and metabolism-based precision therapy.