Myocardial metabolic remodeling in human end-stage ischemic and non-ischemic cardiomyopathy
Human end-stage heart failure is characterized by altered glucose and amino acid metabolism, heightened oxidative stress, increased purine breakdown, and reduced pyrimidine levels, with no differences observed between ischemic and nonischemic cardiomyopathy. These findings enhance our understanding of metabolic alterations in failing human hearts.
Authors
- Courtney J. Christopher (ORCID: https://orcid.org/0000-0002-8387-4779)
- Ryan T. Gross (ORCID: https://orcid.org/0000-0003-4849-0371)
- Gabriel Esmailian (ORCID: https://orcid.org/0000-0002-1820-7910)
- Weiqin Chen (ORCID: https://orcid.org/0000-0002-3894-5953)
- Michelle Mendiola Pla
- Dawn E. Bowles
- Katarina Jones
- Shawn Robert Campagna
- Hongyi Zhou
Institutions
- Augusta University (US)
- Duke Medical Center (US)
- University of Tennessee at Knoxville (US)
Publication Details
- Journal
- Journal of Molecular and Cellular Cardiology
- Published
- 2026-02-27
- DOI
- https://doi.org/10.1016/j.yjmcc.2026.02.008
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00