Factors associated with adherence to allocated treatment in the ASCEND trial: a mail-based randomised trial of aspirin and of omega-3 fatty acid supplementation in people with diabetes
We show this large, mail-based trial has comparable adherence with less streamlined trials in similar populations. In ASCEND, women and those with higher levels of frailty, smoking and vascular risk score had poorer adherence to trial medication. Trialists should consider strategies to improve adherence in these participant groups.
Authors
- Georgina Buck (ORCID: https://orcid.org/0000-0001-5909-4265)
- Louise Bowman (ORCID: https://orcid.org/0000-0003-1125-8616)
- Marion M. Mafham
- Jane Armitage
Institutions
- Oxford Health NHS Foundation Trust (GB)
- University of Oxford (GB)
Publication Details
- Journal
- Trials
- Published
- 2026-02-27
- DOI
- https://doi.org/10.1186/s13063-026-09551-4
- Primary Topic
- Medication Adherence and Compliance
- Type
- article
- Field-Weighted Citation Impact
- 0.00