A targeted metabolomic method to detect epigenetically relevant metabolites

We present an innovative analytical methodology for the simultaneous detection and quantification of over 30 epigenetically relevant metabolites, including short chain fatty acids. Using stable isotope tracing to track the synthesis of S-adenosylmethionine (SAM) and acetyl-Coenzyme A (acetyl-CoA), our method reveals new insights into metabolism linked to epigenetic modifications, including glycolysis, the pentose phosphate pathway, de novo glycine synthesis, and the folate and methionine cycle. Demonstrating practical utility in case-control studies, this approach supports integrative multi-omics strategies to explore the interplay between metabolism and epigenetics across various biological systems and diseases.

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Publication Details

Journal
Molecular Metabolism
Published
2026-02-26
DOI
https://doi.org/10.1016/j.molmet.2026.102342
Primary Topic
Metabolomics and Mass Spectrometry Studies
Type
article
Field-Weighted Citation Impact
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article

A targeted metabolomic method to detect epigenetically relevant metabolites

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Molecular Metabolism
Metabolomics and Mass Spectrometry Studies
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A targeted metabolomic method to detect epigenetically relevant metabolites

Claire Maudet, Sylvie Rabot, Jane Mellor, Óscar Yanes, Aurélie Balvay, Silvia Raineri, Jordi Capellades, Marta Kovatcheva, Alexandra Junza, Joan Miro-Blanch, Manuel Serrano
article en

Abstract

We present an innovative analytical methodology for the simultaneous detection and quantification of over 30 epigenetically relevant metabolites, including short chain fatty acids. Using stable isotope tracing to track the synthesis of S-adenosylmethionine (SAM) and acetyl-Coenzyme A (acetyl-CoA), our method reveals new insights into metabolism linked to epigenetic modifications, including glycolysis, the pentose phosphate pathway, de novo glycine synthesis, and the folate and methionine cycle. Demonstrating practical utility in case-control studies, this approach supports integrative multi-omics strategies to explore the interplay between metabolism and epigenetics across various biological systems and diseases.

Molecular MetabolismVol. 106
AgroParisTech (FR), Université Paris-Saclay (FR), Novo Nordisk Foundation (DK), Microbiologie de l’alimentation au service de la santé (FR), University of Oxford (GB), Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement (FR), Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES), Institute for Research in Biomedicine (ES), Barcelona Institute of Science and Technology (ES), Hospital Universitari Sant Joan de Reus (ES)
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