Heteroresistance to amikacin in <i>Klebsiella aerogenes</i> isolates from patients in an intensive care unit in Brazil

<i>Klebsiella aerogenes</i>, an opportunistic human pathogen, is frequently implicated in severe and invasive infections, particularly in immunocompromised individuals. The growing prevalence of antibiotic resistance among these strains poses a significant therapeutic challenge. The phenomenon of heteroresistance further complicates management, potentially leading to diagnostic difficulties due to the lack of standardized detection methods and subsequent treatment failures. Our studies identified and characterized <i>K. aerogenes</i> strains heteroresistant to amikacin, isolated from patients in an intensive care unit. Such data can serve as a foundational reference for understanding the clinical relevance, genomic variability, and pathogenic potential of <i>K. aerogenes</i> heteroresistance to antibiotics used in clinical settings.

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Publication Details

Journal
Microbiology Spectrum
Published
2026-02-26
DOI
https://doi.org/10.1128/spectrum.02833-25
Primary Topic
Antibiotic Resistance in Bacteria
Type
article
Field-Weighted Citation Impact
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article

Heteroresistance to amikacin in Klebsiella aerogenes isolates from patients in an intensive care unit in Brazil

Roumayne Lopes Ferreira, Rebecca Elizabeth Shilling, João Pedro Maia de Oliveira da Silva, Andrea Soares‐Costa et al.
Microbiology Spectrum
Antibiotic Resistance in Bacteria
article

Heteroresistance to amikacin in Klebsiella aerogenes isolates from patients in an intensive care unit in Brazil

Roumayne Lopes Ferreira, Rebecca Elizabeth Shilling, João Pedro Maia de Oliveira da Silva, Andrea Soares‐Costa, Robert J. Mitchell, Saulo Henrique Rodrigues, Anderson Ferreira da Cunha, Leslie Camelo Campos, Gabriela Guerrera Soares, Gustavo Dantas Nunes, Olinda Soares Athaide Alcobaça, André Pitondo-Silva, Natália Ribeiro Crispim, Maria-Cristina da Silva Pranchevicius
article en

Abstract

<i>Klebsiella aerogenes</i>, an opportunistic human pathogen, is frequently implicated in severe and invasive infections, particularly in immunocompromised individuals. The growing prevalence of antibiotic resistance among these strains poses a significant therapeutic challenge. The phenomenon of heteroresistance further complicates management, potentially leading to diagnostic difficulties due to the lack of standardized detection methods and subsequent treatment failures. Our studies identified and characterized <i>K. aerogenes</i> strains heteroresistant to amikacin, isolated from patients in an intensive care unit. Such data can serve as a foundational reference for understanding the clinical relevance, genomic variability, and pathogenic potential of <i>K. aerogenes</i> heteroresistance to antibiotics used in clinical settings.

Microbiology Spectrum
Universidade de Ribeirão Preto (BR), Universidade Federal de São Carlos (BR), Universidade do Tocantins (BR), Instituto de Saúde (BR), Ulsan National Institute of Science and Technology (KR)
Good health and well-being
Openalex Percentile: Top 41%
Antibiotic Resistance in Bacteria
DOIOpen Access PDFOpenAlex
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