Targeting low-grade inflammation in multiple sclerosis through the Wim Hof method or lifestyle intervention: a pilot comparative study
Both WHM and lifestyle modification demonstrated comparable short-term anti-inflammatory effects in MS, supporting their safety and feasibility as adjunctive strategies to DMT. Although neurodegeneration biomarkers remained unchanged, the consistent reduction of IL-17A and IL-18 highlights their potential to modulate smoldering inflammation. Larger, longer-term trials are warranted to determine their sustained effects on disease progression.
Authors
- Viktor Bielik (ORCID: https://orcid.org/0000-0001-9525-4983)
- Pavol Kadlic
- Michal Pastorek
- Libuša Nechalová
- Michal Minár (ORCID: https://orcid.org/0000-0002-0812-2366)
- L. Sabolova
- František Jurčaga
- Michal Páleník (ORCID: https://orcid.org/0000-0001-6796-9842)
- Ivan Hric
- Darina Slezáková
- Peter Marček
- Norbert Žilka
- Jozef Hanes
- Peter Olej
Institutions
- Slovak Academy of Sciences (SK)
- University Hospital Bratislava (SK)
- Biomedical Research Center of the Slovak Academy of Sciences (SK)
- Institute of Neuroimmunology of the Slovak Academy of Sciences (SK)
- Comenius University Bratislava (SK)
Publication Details
- Journal
- Neurological Sciences
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1007/s10072-026-08895-8
- Primary Topic
- Multiple Sclerosis Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00