Mechanobiological Ultrasound Simulation Reveals Suppression of Epithelial-to-Mesenchymal Transition and Stemness Programs in Colorectal Cancer

Early mechanistic understanding of how acoustic force-based ultrasound may inhibit EMT and stemness in CRC is provided by this transcriptome simulation. This data-driven approach presents ultrasound as a promising supplement to immune-oncology and antimetastatic methods and encourages more <i>in vitro</i> validation.

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Publication Details

Journal
Cancer Biotherapy and Radiopharmaceuticals
Published
2026-02-25
DOI
https://doi.org/10.1177/10849785261422983
Primary Topic
Cancer Cells and Metastasis
Type
article
Field-Weighted Citation Impact
0.00
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article

Mechanobiological Ultrasound Simulation Reveals Suppression of Epithelial-to-Mesenchymal Transition and Stemness Programs in Colorectal Cancer

Jianzhong Chen, Pei Nan Wen, Ming shu Lin
Cancer Biotherapy and Radiopharmaceuticals
Cancer Cells and Metastasis
article

Mechanobiological Ultrasound Simulation Reveals Suppression of Epithelial-to-Mesenchymal Transition and Stemness Programs in Colorectal Cancer

Jianzhong Chen, Pei Nan Wen, Ming shu Lin
article en

Abstract

Early mechanistic understanding of how acoustic force-based ultrasound may inhibit EMT and stemness in CRC is provided by this transcriptome simulation. This data-driven approach presents ultrasound as a promising supplement to immune-oncology and antimetastatic methods and encourages more <i>in vitro</i> validation.

Cancer Biotherapy and Radiopharmaceuticals
Wenzhou Medical University (CN), First Affiliated Hospital of Wenzhou Medical University (CN)
Openalex Percentile: Top 41%
Cancer Cells and Metastasis
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