Severity of surgical histopathological fibrosis predicted postoperative recurrence in Crohn’s disease: a multi-center retrospective cohort study
The severity of intestinal fibrosis in both lesion site and resection margin independently predicted an increased risk of postoperative endoscopic and clinical recurrence in CD. Histopathological fibrosis assessment may help identify high-risk individuals prone to postoperative recurrence, potentially informing personalized postoperative management strategies.
Authors
- Weitong Gao
- X Q Wang
- Duowu Zou (ORCID: https://orcid.org/0000-0002-2461-5304)
- Shuowen Zhang (ORCID: https://orcid.org/0000-0002-1466-1788)
- Tianyi Che (ORCID: https://orcid.org/0009-0007-1402-9583)
- Yubei Gu
- Shenglan You
- Yiwen Tu
- Y Zhang
- Ren Mao
- Yi Li
- Jing Sun
- Lingying Zhao
- Zirui He
Institutions
- Sun Yat-sen University (CN)
- Ruijin Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Jinling Institute of Technology (CN)
Publication Details
- Journal
- Journal of Gastroenterology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1007/s00535-026-02374-9
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation