Lenvatinib plus Pembrolizumab for Patients with Previously Treated Advanced Gastric, Biliary Tract, or Pancreatic Cancer: Results from the Phase II LEAP-005 Study
In the phase II LEAP-005 study, lenvatinib plus pembrolizumab showed modest antitumor activity and a manageable safety profile in participants with previously treated gastrointestinal-related cancers. Exploratory analyses in participants with BTC indicated higher ORRs in participants with targetable alterations versus those without.
Authors
- Daniel Heudobler (ORCID: https://orcid.org/0000-0002-8790-4584)
- Carlos Gomez‐Roca (ORCID: https://orcid.org/0000-0002-8043-2529)
- Ronnie Shapira-Frommer
- Chinyere E. Okpara (ORCID: https://orcid.org/0000-0002-5621-9138)
- Sanjeev Gill
- A. Santoro
- Roman Groisberg (ORCID: https://orcid.org/0000-0001-8970-7675)
- Razi Ghori (ORCID: https://orcid.org/0009-0004-3095-8612)
- Ravit Geva
- Corina E. Dutcus (ORCID: https://orcid.org/0000-0003-3483-716X)
- Amir Vajdi (ORCID: https://orcid.org/0000-0001-8271-8566)
- Yiwei Zhang (ORCID: https://orcid.org/0000-0003-1751-6006)
- Feng Jin (ORCID: https://orcid.org/0000-0002-4450-6084)
- Giampaolo Tortora
- EJ Dettman
- Mariano Ponz-Sarvise
- Tae Won. Kim
- Laura Ortega Morán
- Esma Saada-Bouzid
Institutions
- Università Cattolica del Sacro Cuore (IT)
- Humanitas University (IT)
- Yonsei University (KR)
- Tel Aviv Sourasky Medical Center (IL)
- Sheba Medical Center (IL)
- Asan Medical Center (KR)
- The Alfred Hospital (AU)
- Agostino Gemelli University Polyclinic (IT)
- Hospital General Universitario Gregorio Marañón (ES)
- University Hospital Regensburg (DE)
- University of Ulsan (KR)
- Institut universitaire du cancer de Toulouse Oncopole (FR)
- Merck Institute for Science Education (US)
- Nutrasource (CA)
- Clinica Universidad de Navarra (ES)
- Cognition Behaviour Technology (FR)
- Eisai (United Kingdom) (GB)
- Centre Antoine Lacassagne (FR)
- IRCCS Humanitas Research Hospital (IT)
- Universidad de Navarra (ES)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1158/2767-9764.crc-26-0018
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eisai