Lenvatinib plus Pembrolizumab for Patients with Previously Treated Advanced Gastric, Biliary Tract, or Pancreatic Cancer: Results from the Phase II LEAP-005 Study

In the phase II LEAP-005 study, lenvatinib plus pembrolizumab showed modest antitumor activity and a manageable safety profile in participants with previously treated gastrointestinal-related cancers. Exploratory analyses in participants with BTC indicated higher ORRs in participants with targetable alterations versus those without.

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Publication Details

Journal
Cancer Research Communications
Published
2026-02-26
DOI
https://doi.org/10.1158/2767-9764.crc-26-0018
Primary Topic
Cholangiocarcinoma and Gallbladder Cancer Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Lenvatinib plus Pembrolizumab for Patients with Previously Treated Advanced Gastric, Biliary Tract, or Pancreatic Cancer: Results from the Phase II LEAP-005 Study

Daniel Heudobler, Carlos Gomez‐Roca, Ronnie Shapira-Frommer, Chinyere E. Okpara et al.
Cancer Research Communications
Cholangiocarcinoma and Gallbladder Cancer Studies
article

Lenvatinib plus Pembrolizumab for Patients with Previously Treated Advanced Gastric, Biliary Tract, or Pancreatic Cancer: Results from the Phase II LEAP-005 Study

Daniel Heudobler, Carlos Gomez‐Roca, Ronnie Shapira-Frommer, Chinyere E. Okpara, Sanjeev Gill, A. Santoro, Roman Groisberg, Razi Ghori, Ravit Geva, Corina E. Dutcus, Amir Vajdi, Yiwei Zhang, Feng Jin, Giampaolo Tortora, EJ Dettman, Mariano Ponz-Sarvise, Tae Won. Kim, Laura Ortega Morán, Esma Saada-Bouzid
article en

Abstract

In the phase II LEAP-005 study, lenvatinib plus pembrolizumab showed modest antitumor activity and a manageable safety profile in participants with previously treated gastrointestinal-related cancers. Exploratory analyses in participants with BTC indicated higher ORRs in participants with targetable alterations versus those without.

Cancer Research CommunicationsVol. 6(3)
Università Cattolica del Sacro Cuore (IT), Humanitas University (IT), Yonsei University (KR), Tel Aviv Sourasky Medical Center (IL), Sheba Medical Center (IL), Asan Medical Center (KR), The Alfred Hospital (AU), Agostino Gemelli University Polyclinic (IT), Hospital General Universitario Gregorio Marañón (ES), University Hospital Regensburg (DE), University of Ulsan (KR), Institut universitaire du cancer de Toulouse Oncopole (FR), Merck Institute for Science Education (US), Nutrasource (CA), Clinica Universidad de Navarra (ES), Cognition Behaviour Technology (FR), Eisai (United Kingdom) (GB), Centre Antoine Lacassagne (FR), IRCCS Humanitas Research Hospital (IT), Universidad de Navarra (ES)
Eisai
Good health and well-being
Openalex Percentile: Top 43%
Cholangiocarcinoma and Gallbladder Cancer Studies
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