Family history enrichment in Non-Small cell Lung Cancer: A cross-sectional − prospective study to inform referral for germline testing
In this prospective observational study, a standardized and weighted assessment of family history identified a clinically meaningful subset of patients with NSCLC enriched for familial cancer patterns. This framework provides a pragmatic approach to optimize referral to genetic counseling and supports targeted germline screening strategies beyond traditional smoking-based risk models. Prospective validation in the planned translational phase will clarify the clinical utility of this approach.
Authors
- M. Russano
- F.M. Venanzi (ORCID: https://orcid.org/0009-0002-5674-8280)
- Francesco Pantano (ORCID: https://orcid.org/0000-0002-2894-9686)
- Fiorella Gurrieri (ORCID: https://orcid.org/0000-0002-6775-5972)
- Priscilla Cascetta (ORCID: https://orcid.org/0000-0002-4252-7543)
- Fabrizio Citarella (ORCID: https://orcid.org/0000-0003-3096-4452)
- A. Cortellini
- Giulia La Cava
- E. Milanesi
- B. Vincenzi
- Sara Oresti (ORCID: https://orcid.org/0009-0006-3879-2092)
- A Delmonte
- Emanuele Claudio Mingo (ORCID: https://orcid.org/0009-0009-2918-7693)
- Massimo Di Maio
- Tiziana Vavalà
- Roberto Ferrara
- Pierfilippo Crucitti
- Giuseppe Tonini
- Kazuki Takada
- Carla Lintas
- Giulia Di Giovanni
- Mattero Fiorenti
- Lucio Crinò
Institutions
- Vita-Salute San Raffaele University (IT)
- Università Campus Bio-Medico (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IT)
- Humanitas Gavazzeni (IT)
- IRCCS Ospedale San Raffaele (IT)
- Campus Bio Medico University Hospital (IT)
- Saiseikai Fukuoka General Hospital (JP)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Lung Cancer
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1016/j.lungcan.2026.109346
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00