Mutant p53 and TP53 mutations in esophageal squamous cell carcinoma: consistency and diagnostic significance

Mutant p53 expression can serve as an alternative marker for TP53 mutation screening used WES or WGS. Mutant p53 expression shows high sensitivity and specificity in distinguishing ESCC and can assist in differentiating benign from malignant esophageal lesions. Five mutant p53 expression subtypes were identified in this study; however, their clinical significance requires further investigation.