Molecular characterization of pediatric mastocytosis revealed different somatic mutations with uncertain prognostic value
c-<i>KIT</i> mutations resulted in 35% of the children tested. The RT-PCR technique resulted more sensitive in finding c-<i>KIT</i> D816V, while NGS in detecting other mutations whose prognostic roles require further investigation.
Authors
- F. Giona
- G. Palumbo
- Michela Ribersani (ORCID: https://orcid.org/0000-0003-4281-4101)
- M. Breccia
- Deborah Kasmi (ORCID: https://orcid.org/0009-0008-7559-6095)
- Giorgio Sforzini
Institutions
- Policlinico Umberto I (IT)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fcell.2026.1780799
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.00