Association of alkaline phosphatase, γ-glutamyl transferase, total bilirubin, and bile acid levels with HCC risk: a systematic review and meta-analysis

This meta-analysis suggests that elevated ALP, GGT, and TB might be associated with new-onset HCC, emphasizing the importance of monitoring these cholestasis-related parameters in clinical practice. BA could not be analyzed due to the small number of studies and the differences in reporting.

Authors

Institutions

Publication Details

Journal
European journal of medical research
Published
2026-02-26
DOI
https://doi.org/10.1186/s40001-026-04093-6
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Association of alkaline phosphatase, γ-glutamyl transferase, total bilirubin, and bile acid levels with HCC risk: a systematic review and meta-analysis

Hong Zhao, Ying Cao, Ligai Liu, You Deng et al.
European journal of medical research
Liver Disease Diagnosis and Treatment
article

Association of alkaline phosphatase, γ-glutamyl transferase, total bilirubin, and bile acid levels with HCC risk: a systematic review and meta-analysis

Hong Zhao, Ying Cao, Ligai Liu, You Deng, Wen Xie
article en

Abstract

This meta-analysis suggests that elevated ALP, GGT, and TB might be associated with new-onset HCC, emphasizing the importance of monitoring these cholestasis-related parameters in clinical practice. BA could not be analyzed due to the small number of studies and the differences in reporting.

European journal of medical research
National Clinical Research Center for Digestive Diseases (CN), Beijing Ditan Hospital (CN)
Good health and well-being
Openalex Percentile: Top 43%
Liver Disease Diagnosis and Treatment
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.