Emodin inhibits breast tumorigenesis in the comorbidity of hyperlipidemia and associated with IL-17 suppression
Emodin effectively reduced tumorigenesis in HFD mice, accompanied with inhibited IL-17 expression and suppressed macrophage infiltration. This result provided evidence for the pro-tumorigenic role of hyperlipidemia in breast cancer development, and support the natural compound Emodin as a promising anti-tumor agent with targeting IL-17 signaling molecules.
Authors
- Qing Liu
- Qingqing Liu
- Qing Liu
- Peizhong Liu
Institutions
- Jilin University (CN)
- Hospital of Hebei Province (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Zhuhai Hospital of Integrated Traditional Chinese and Western Medicine (CN)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1016/j.bbrep.2026.102520
- Primary Topic
- Phytochemistry and biological activity of medicinal plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Guangzhou University
- Guangzhou Municipal Science and Technology Bureau