CoQ0 hysteresis and inhibition of the cytochrome b5 reductase activity of human Cb5R by CoQ0 and CoQ10
Both quinones inhibit the NADH: cytochrome b<sub>5</sub> reductase activity of human Cb<sub>5</sub>R isoforms, but only CoQ<sub>0</sub> triggers hysteresis in the soluble Cb<sub>5</sub>R isoform. Our data support the use of fully soluble components for studying hysteresis in this system, as they recapitulate key features of the behavior observed in biological membranes.
Authors
- Cristina M. Cordas (ORCID: https://orcid.org/0000-0002-7892-8955)
- Gabriel N. Valério (ORCID: https://orcid.org/0000-0002-7030-8372)
- Alejandro K. Samhan‐Arias
- Carlos Sanchez-Cabeza
- Oscar H. Martinez-Costa
Institutions
- Instituto de Investigaciones Biomédicas Sols-Morreale (ES)
- Rede de Química e Tecnologia (PT)
- Universidad Autónoma de Madrid (ES)
- Universidade Nova de Lisboa (PT)
Publication Details
- Journal
- Free Radical Biology and Medicine
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1016/j.freeradbiomed.2026.02.065
- Primary Topic
- Porphyrin Metabolism and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00