Near-Infrared Fluorescence Lifetime Imaging Microscopy Reveals Loss of RPE Cell Body Polarity in Age-Related Macular Degeneration
At 780 nm, FLIM detects a loss of RPE cell polarity that likely reflects intracellular reorganization and metabolic change. Disruption in NIR-autofluorescence lifetimes may provide an early biomarker for pathological RPE alterations in AMD.
Authors
- Katharina Wall (ORCID: https://orcid.org/0000-0003-3420-0054)
- Niko Schwenzer (ORCID: https://orcid.org/0000-0003-0794-5501)
- Marc Vaisband (ORCID: https://orcid.org/0000-0003-4721-0315)
- Thomas Ach
- Anna Jauch
- Jan Hasenauer
- Leon von der Emde
- Christine A. Curcio
- Frank G. Holz
- Sebastian Fritsch
Institutions
- University of Bonn (DE)
- University Hospital Bonn (DE)
- University of Alabama at Birmingham (US)
- Life & Brain (Germany) (DE)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1167/iovs.67.2.55
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00