A 7-gene expression signature predicts immune microenvironment remodeling and neoadjuvant chemo-immunotherapy response in lung squamous cell carcinoma
NCI altered the TME and was linked to treatment response in LUSC. Identifying predictors of immunotherapy efficacy, such as <i>HOXC13</i>, provides potential strategies to overcome resistance in clinical practice.
Authors
- T. Hu
- Likun Hou
- Junhong Guo (ORCID: https://orcid.org/0000-0003-0703-9939)
- S. Li
- Chunyan Wu (ORCID: https://orcid.org/0009-0005-2118-7518)
- Yao Xiao (ORCID: https://orcid.org/0000-0002-0194-8253)
- Zhengwei Dong
- Huifang Liu (ORCID: https://orcid.org/0009-0002-3982-355X)
- C. Zhu
- Yan Huang
- Jin Wang
- Ranyue Wang
- Xing Li
- Zhan Huang
Institutions
- Nanchang University (CN)
- Shanghai Pulmonary Hospital (CN)
- Dian Diagnostics (China) (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-26
- DOI
- https://doi.org/10.3389/fimmu.2026.1696792
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00