Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis
ITPA activity is a promising predictive biomarker for MTX response in JIA, outperforming ITPA rs1127354 genotyping. Its predictive value is evident at treatment initiation, supporting its use for personalized treatment. Mechanistically, higher enzyme activity may enhance MTX efficacy through the adenosine/inosine-ADORA<sub>2A</sub> pathway.
Authors
- Debora Curci (ORCID: https://orcid.org/0000-0002-3273-9489)
- Barbara Bellich (ORCID: https://orcid.org/0000-0002-5257-6584)
- Martina Franzin (ORCID: https://orcid.org/0000-0003-1304-6190)
- Gabriele Stocco (ORCID: https://orcid.org/0000-0003-0964-5879)
- Sofia Pagarin
- Valentina Moressa (ORCID: https://orcid.org/0000-0001-7956-5431)
- Davide Selvestrel
- Giuliana Decorti
- Marianna Lucafò (ORCID: https://orcid.org/0000-0003-1355-3782)
- Mara L. Becker
- J. Kevin Hicks
- S D Thompson
- Sofia Sindici Forgiarini
- Carl D Langefeld
- Andrea Taddio
- Alberto Tommasini
- Gabriele Simonini
- Federica Corba
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Children's Mercy Hospital (US)
- University of Trieste (IT)
- Duke University (US)
- IRCCS Materno Infantile Burlo Garofolo (IT)
- Meyer Children's Hospital (IT)
- Wake Forest University (US)
- University of Missouri–Kansas City (US)
- International Centre for Genetic Engineering and Biotechnology (IT)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2026-03-08
- DOI
- https://doi.org/10.1002/art.70097
- Primary Topic
- Autoimmune and Inflammatory Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00