Active bone marrow dose reconstruction in a large‐scale cohort study of cancer patients treated with photon radiotherapy
This study presents a scalable EMR-based approach for reconstructing ABM dose and dose-volume metrics in EBRT patients. By capturing clinically relevant dose heterogeneity, we have estimated a more informative exposure variable than mean ABM dose for studies on the role of radiotherapy in leukemogenesis and other adverse health effects. Future work will improve the generalizability of these methods for certain treatment regions and pediatric populations.
Authors
- Lior Z. Braunstein (ORCID: https://orcid.org/0000-0002-5127-0217)
- Kelly Bolton (ORCID: https://orcid.org/0000-0003-3543-8339)
- Kishan Pithadia
- L. M. Morton
- Choonsik Lee
- Keith T Griffin
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Yonsei University (KR)
- Washington University in St. Louis (US)
- National Cancer Institute (US)
- Division of Cancer Epidemiology and Genetics
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Journal of Applied Clinical Medical Physics
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1002/acm2.70494
- Primary Topic
- Advanced Radiotherapy Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00