Model‐Based Strategy for 6‐Mercaptopurine Treatment in Acute Lymphoblastic Leukemia Maintenance Phase: Prediction of 6‐TGN and 6‐MMP Concentrations to Optimize Treatment
Allopurinol co-treatment reduces toxicity while maintaining therapeutic efficacy at lower 6-MP doses. The proposed model warrants prospective evaluation for clinical relevance confirmation.
Authors
- Monia Guidi
- C Csajka
- Anne Ravix
- Francesco Ceppi
- Anaïs Maillat
- Eva Choong
Institutions
- University of Geneva (CH)
- HES-SO University of Applied Sciences and Arts Western Switzerland (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1002/1545-5017.70167
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00