Evaluating the Efficacy of Nebulized Ciprofloxacin‐Dexamethasone Using a Novel Model of Airway Stenosis
This novel open surgical model reliably induces mixed mucosal and structural airway stenosis, offering precise control over the injury site. Additionally, this study provides the first quantitative evidence of therapeutic potential for nebulized ciprofloxacin/dexamethasone, demonstrating attenuated mucosal inflammation and airway narrowing, and presents a reproducible model for the preclinical evaluation of airway stenosis treatments.
Authors
- Pooja Swami (ORCID: https://orcid.org/0000-0002-8184-4605)
- Rachel Kaye
- Matthew I. Saleem (ORCID: https://orcid.org/0000-0003-2943-8500)
- Travis Peng
- Daniel A. Grande (ORCID: https://orcid.org/0000-0003-0760-8185)
- Patrick Scheffler
- Lee P Smith
Institutions
- Rutgers, The State University of New Jersey (US)
- Feinstein Institute for Medical Research (US)
- Hofstra University (US)
- University of Kansas (US)
- Lenox Hill Hospital (US)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
- Cohen Children's Medical Center (US)
- Shoolini University (IN)
- North Shore Diabetes and Endocrine Associates (US)
- Rutgers New Jersey Medical School (US)
Publication Details
- Journal
- Otolaryngology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1002/ohn.70173
- Primary Topic
- Tracheal and airway disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00