FLASH radiotherapy preserves systemic and tissue homeostasis while maintaining antitumor efficacy
FLASH-RT provides effective tumor control while largely preserving normal tissues. CONV-RT and FLASH-RT elicit substantially different biological responses, suggesting the involvement of upstream modulators that vary depending on the dose rate.
Authors
- Eduarda Mota‐Silva (ORCID: https://orcid.org/0000-0002-4305-8216)
- M. J. C. Costa
- Alice Usai (ORCID: https://orcid.org/0000-0003-0226-837X)
- Riccardo Berutti (ORCID: https://orcid.org/0000-0003-1862-3700)
- Fabiola Paiar
- Jessica Milia
- Francesco Faita (ORCID: https://orcid.org/0000-0002-6201-1843)
- Claudia Kusmic (ORCID: https://orcid.org/0000-0002-8064-8311)
- Alessandra Gonnelli (ORCID: https://orcid.org/0000-0002-4087-1949)
- Roberto Cusano (ORCID: https://orcid.org/0000-0001-5543-7881)
- Federico Rossi (ORCID: https://orcid.org/0000-0001-8293-9457)
- Giulia Furini (ORCID: https://orcid.org/0000-0001-7206-7720)
- Stefano Lattanzio
- Emanuela Guerra (ORCID: https://orcid.org/0000-0002-7091-8621)
- Fabio Di Martino (ORCID: https://orcid.org/0000-0002-3750-8487)
- Noemi Giannini
- Gaia Scabia (ORCID: https://orcid.org/0000-0002-1603-4585)
- S. Capaccioli (ORCID: https://orcid.org/0000-0003-4866-8918)
- Sergio Castorina (ORCID: https://orcid.org/0000-0002-0745-4107)
- Margherita Maffei (ORCID: https://orcid.org/0000-0002-8534-2450)
- Mariagrazia Celentano
- Giulia Asero
- Tonia Luca
- Roberta Di Pietro
- Andrea Cavalieri
- Saverio Cinti
Institutions
- University of Pisa (IT)
- Marche Polytechnic University (IT)
- Istituto di Scienza e Tecnologie dell'Informazione "Alessandro Faedo" (IT)
- Center for Advanced Studies Research and Development in Sardinia (IT)
- University of Catania (IT)
- University of Chieti-Pescara (IT)
- Istituto di Fisiologia Clinica (IT)
- Consorzio Pisa Ricerche (IT)
- Neuroscience Institute (IT)
- National Research Council (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
Publication Details
- Journal
- BMC Medicine
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1186/s12916-026-04724-z
- Primary Topic
- Effects of Radiation Exposure
- Type
- article
- Field-Weighted Citation Impact
- 0.00