FLASH radiotherapy preserves systemic and tissue homeostasis while maintaining antitumor efficacy

FLASH-RT provides effective tumor control while largely preserving normal tissues. CONV-RT and FLASH-RT elicit substantially different biological responses, suggesting the involvement of upstream modulators that vary depending on the dose rate.

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Publication Details

Journal
BMC Medicine
Published
2026-02-26
DOI
https://doi.org/10.1186/s12916-026-04724-z
Primary Topic
Effects of Radiation Exposure
Type
article
Field-Weighted Citation Impact
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article

FLASH radiotherapy preserves systemic and tissue homeostasis while maintaining antitumor efficacy

Eduarda Mota‐Silva, M. J. C. Costa, Alice Usai, Riccardo Berutti et al.
BMC Medicine
Effects of Radiation Exposure
article

FLASH radiotherapy preserves systemic and tissue homeostasis while maintaining antitumor efficacy

Eduarda Mota‐Silva, M. J. C. Costa, Alice Usai, Riccardo Berutti, Fabiola Paiar, Jessica Milia, Francesco Faita, Claudia Kusmic, Alessandra Gonnelli, Roberto Cusano, Federico Rossi, Giulia Furini, Stefano Lattanzio, Emanuela Guerra, Fabio Di Martino, Noemi Giannini, Gaia Scabia, S. Capaccioli, Sergio Castorina, Margherita Maffei, Mariagrazia Celentano, Giulia Asero, Tonia Luca, Roberta Di Pietro, Andrea Cavalieri, Saverio Cinti
article en

Abstract

FLASH-RT provides effective tumor control while largely preserving normal tissues. CONV-RT and FLASH-RT elicit substantially different biological responses, suggesting the involvement of upstream modulators that vary depending on the dose rate.

BMC Medicine
University of Pisa (IT), Marche Polytechnic University (IT), Istituto di Scienza e Tecnologie dell'Informazione "Alessandro Faedo" (IT), Center for Advanced Studies Research and Development in Sardinia (IT), University of Catania (IT), University of Chieti-Pescara (IT), Istituto di Fisiologia Clinica (IT), Consorzio Pisa Ricerche (IT), Neuroscience Institute (IT), National Research Council (IT), Azienda Ospedaliera Universitaria Pisana (IT)
Zero hunger
Openalex Percentile: Top 44%
Effects of Radiation Exposure
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