Age-specific risk of malignancy in pediatric thyroid cytology: Reframing ROM based on pre-test probability
Age substantially modifies both pretest and post-test malignancy probabilities in paediatric thyroid cytology. An age-stratified LR framework helps quantify verification bias and provides individualized risk estimates to guide decisions about surgery, molecular testing, and follow-up.
Authors
- Anna Maria Carillo (ORCID: https://orcid.org/0000-0002-0870-258X)
- Mehmet Güven Günver (ORCID: https://orcid.org/0000-0002-4628-8391)
- H Wang
- Helena Barroca (ORCID: https://orcid.org/0000-0001-5684-3523)
- Şule Canberk (ORCID: https://orcid.org/0000-0002-3736-1323)
- Hasan Güçer (ORCID: https://orcid.org/0000-0002-9122-379X)
- Eleni Thodou (ORCID: https://orcid.org/0000-0003-4988-1526)
- Amber Isaza (ORCID: https://orcid.org/0000-0003-0863-7500)
- Filippo Dello Iacovo
- Ozlem Aydin
- Claudio Bellevicine (ORCID: https://orcid.org/0000-0002-7479-6457)
- Mya Bojarsky (ORCID: https://orcid.org/0000-0003-0629-0160)
- Schmitt Fc
- Mariana Simplício
- Serra Zeynep Akkoyunlu
- Elisabete Rodrigues
- João Capela
- Elena Vigliar
- Vivian L. Weiss
- Giancarlo Troncone
- Zubair W Baloch
- Andrew J Bauer
Institutions
- Children's Hospital of Philadelphia (US)
- University of Thessaly (GR)
- Recep Tayyip Erdoğan University (TR)
- Universidade do Porto (PT)
- Hospital de São João (PT)
- Administração Regional de Saúde de Lisboa e Vale do Tejo (PT)
- Kent Hastanesi (TR)
- Istanbul University (TR)
- University of Naples Federico II (IT)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1210/clinem/dgag073
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00