Machine learning-derived AS and AIS scores leverage BCAA metabolism and IL4I1 activity for prognosis and tailored therapy in ccRCC
Branched-chain amino acid metabolism and IL4I1 are pivotal in the progression of ccRCC. AS classification and the AIS score present a robust framework for personalized treatment strategies, while IL4I1 shows potential as a novel therapeutic target to enhance treatment efficacy.
Authors
- X. Li
- Kang qiang Weng
- Linlin Liu (ORCID: https://orcid.org/0000-0002-1058-4551)
- X. Y. Chen
- Jun wei Lin
- Ruo yun Xie
- Le ye Yan
Institutions
- Fujian Medical University (CN)
- Union Hospital (US)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-02-25
- DOI
- https://doi.org/10.3389/fcell.2026.1720910
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00