Autosomal Dominant Hyper‐ <scp>IgE</scp> Syndrome Patients Retain <scp>IL10</scp> ‐Producing <scp>preTh17</scp> ‐Cells That Are Activated by Opportunistic Pathogens and Support <scp>IgE</scp> Production
Th17 differentiation in AD-HIES patients was not completely impaired but arrested at an intermediate stage of IL-10-producing "pre-Th17"-cells. Surprisingly, DN-STAT3 mutations did not inhibit IL-10 production by CD4<sup>+</sup>T-cells. Pre-Th17-cells were activated by AD-HIES-associated pathogens and possessed B-helper functions, suggesting that they are not protective but may promote aberrant IgE production.
Authors
- Chiara Vasco (ORCID: https://orcid.org/0000-0002-3788-778X)
- Manal Bel Imam (ORCID: https://orcid.org/0000-0002-7352-7204)
- Jens Geginat (ORCID: https://orcid.org/0000-0003-4813-0384)
- Maria Carrabba (ORCID: https://orcid.org/0000-0002-0717-9096)
- Francesca Clemente (ORCID: https://orcid.org/0000-0002-9899-0836)
- Nadia Pulvirenti (ORCID: https://orcid.org/0000-0001-7175-7412)
- Lucia Augusta Baselli (ORCID: https://orcid.org/0000-0003-1171-1185)
- Loris Rizzello (ORCID: https://orcid.org/0000-0002-8230-853X)
- Mariacristina Crosti (ORCID: https://orcid.org/0000-0001-8314-1391)
- Giorgia Moschetti (ORCID: https://orcid.org/0000-0001-7763-4421)
- Elena Carelli (ORCID: https://orcid.org/0009-0002-5582-9548)
- Dellepiane Rm
- Maria Lucia Sarnicola (ORCID: https://orcid.org/0000-0002-0283-8849)
- Sara Maioli (ORCID: https://orcid.org/0009-0006-2513-3098)
- Sergio Abrignani
- Edoardo Scarpa
- Giovanna Fabio
- Paola Larghi
- Willem van de Veen
Institutions
- University of Milan (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Istituto Nazionale Genetica Molecolare (IT)
Publication Details
- Journal
- Allergy
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1111/all.70266
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00