The predictive value of polygenic risk scores for depression in gene-environment interaction studies: a systematic review
Two general conclusions can be drawn from this review. First, PRS<sub>D</sub>xE interactions, if at all, add a small amount of explained variance in depression phenotypes to the corresponding additive model and may thus require large samples to be reliably detected. Second, in a considerable number of studies, different environmental exposures were found to depend on an individual's PRS<sub>D</sub>, indicating significant gene-environment correlation. We further discuss limitations, future directions and potential clinical relevance of PRSxE research in depression.
Authors
- Susanne Vogel (ORCID: https://orcid.org/0000-0001-9717-5568)
- Nina Alexander (ORCID: https://orcid.org/0009-0002-7412-0163)
- Sabrina Illius (ORCID: https://orcid.org/0000-0002-7736-0149)
- Julian Eder
Institutions
- Philipps University of Marburg (DE)
- MSH Medical School Hamburg – University of Applied Sciences and Medical University (DE)
- Technische Universität Dresden (DE)
Publication Details
- Journal
- Translational Psychiatry
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1038/s41398-025-03793-7
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft