Combined Tyrosine Kinase Inhibitors and Chemotherapy Based on Minimal Residual Disease in Children With Ph <sup>+</sup> Acute Lymphoblastic Leukemia: A Phase 2 Single‐Arm Trial, JCCG ALL‐Ph13
Compared with Ph+ALL04, HSCT was substantially reduced in ALL-Ph13 while maintaining comparable outcomes. Further optimization of treatment, particularly the duration of TKI administration, is needed to maintain long-term EFS.
Authors
- Yuichi Kodama (ORCID: https://orcid.org/0000-0003-1314-0371)
- Hidefumi Hiramatsu (ORCID: https://orcid.org/0000-0003-3136-5670)
- Hirohide Kawasaki
- Chiyo K. Imamura (ORCID: https://orcid.org/0000-0003-2907-847X)
- Yoshiyuki Kosaka
- Daisuke Hasegawa (ORCID: https://orcid.org/0000-0002-7554-9108)
- M. Kato (ORCID: https://orcid.org/0000-0003-1276-5206)
- Sachiko Yonezawa
- Takao Deguchi (ORCID: https://orcid.org/0000-0001-9932-4299)
- Kimiyoshi Sakaguchi (ORCID: https://orcid.org/0000-0002-3665-401X)
- Atsushi Manabe (ORCID: https://orcid.org/0000-0002-6698-2348)
- Koji Kato (ORCID: https://orcid.org/0000-0002-7397-1575)
- Akiko Inoue (ORCID: https://orcid.org/0000-0002-6758-8254)
- Haruko Shima (ORCID: https://orcid.org/0000-0003-3432-8832)
- Masaki Yamamoto (ORCID: https://orcid.org/0000-0002-0288-7990)
- Nobutaka Kiyokawa (ORCID: https://orcid.org/0000-0001-9310-2126)
- Y. Iijima-Yamashita
- Atsushi Sato (ORCID: https://orcid.org/0009-0009-5276-9667)
- Etsuro Ito
- Koichi Oshima
- Akiko Kada
- Keizo Horibe
- Hirotoshi Sakaguchi
- Kentaro Ohki
- Yoshiko Hashii
- Hiroyuki Shimada
Institutions
- SHOWA Medical University (JP)
- Sapporo Medical University (JP)
- Hirosaki University (JP)
- Keio University (JP)
- Hokkaido University (JP)
- Kyoto University (JP)
- Hamamatsu University School of Medicine (JP)
- St. Luke's International Hospital (JP)
- Miyagi Children's Hospital (JP)
- Saitama Children's Medical Center (JP)
- Matsuyama Red Cross Hospital (JP)
- Kagoshima University Hospital (JP)
- Kobe Children's Hospital (JP)
- National Center For Child Health and Development (JP)
- Gunma Children's Medical Center (JP)
- Nagoya Medical Center (JP)
- Ibaraki Children's Hospital (JP)
- The University of Tokyo (JP)
- Osaka University of Pharmaceutical Sciences (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Pediatric Blood & Cancer
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1002/1545-5017.70173
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00