Insulin resistance and metabolic health predict cardiorespiratory fitness: cohort study
In a cohort of individuals without established CVD, the main determinants of CRF were modifiable risk factors associated with excess adiposity and insulin resistance. The potential mechanisms underlying the reduction in CRF include decreased relative muscle mass and insulin resistance, which reduce muscle glucose uptake and O<sub>2</sub> consumption during maximum effort, where anaerobic glycolysis plays a central role.
Authors
- Fabiola Mabel Del Razo-Olvera (ORCID: https://orcid.org/0000-0002-7266-5381)
- Ana Leonor Rivera (ORCID: https://orcid.org/0000-0002-0296-7966)
- Donají Gómez‐Velasco (ORCID: https://orcid.org/0000-0001-9648-4932)
- Gabriela A. Galán-Ramírez (ORCID: https://orcid.org/0000-0002-4224-9619)
- L Muñoz-Hernández
- Guillermo Roa-Álvarez
- Antonio Barajas-Martínez
- Jesus Paez-Mayorga
- Erick Resendiz-Carrillo
- Leticia Lopez-Carreola
- Sebastian Zamora-Gutierrez
- Eunice Barbosa-Meillon
- Carlos A Aguilar-Salinas
- Adrian Soto-Mota
- Jesus Flores-Brito
- Perla Alpizar-Chacon
Institutions
- Universidad Autónoma de la Ciudad de México (MX)
- Secretaria de Salud (MX)
- Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
- Universidad Insurgentes (MX)
- Secretaría de Ciencia, Humanidades, Tecnología e Innovación (MX)
- Universidad Nacional Autónoma de México (MX)
- Tecnológico de Monterrey (MX)
Publication Details
- Journal
- European Heart Journal Open
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1093/ehjopen/oeag029
- Primary Topic
- Cardiovascular and exercise physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00