NQO1-Mediated Oxidative Stress Resistance and Tumor Microenvironment Remodeling in Glioblastoma
NQO1 plays critical roles at both the cell-autonomous and cell-extrinsic levels for clinical treatment. Targeting NQO1 and its downstream signaling pathways, including β-Lapachone and immune checkpoint inhibitors such as anti-PD-1 therapy, enhances our understanding of the interactions between GSCs, oxidative stress, and the TME. This offers promising new avenues for clinical intervention in GBM.
Authors
- Daqi Li (ORCID: https://orcid.org/0000-0002-7448-7435)
- Kailin Yang (ORCID: https://orcid.org/0000-0001-5968-6738)
- Jiancheng Gao (ORCID: https://orcid.org/0009-0006-0927-5088)
- Zhumei Shi (ORCID: https://orcid.org/0000-0003-1664-7135)
- Jeremy N. Rich (ORCID: https://orcid.org/0000-0001-7845-5302)
- Q Zhang
- Luan Sun (ORCID: https://orcid.org/0009-0004-7560-4826)
- Chenfei Lu (ORCID: https://orcid.org/0000-0002-6217-3869)
- Yangqing Li (ORCID: https://orcid.org/0009-0004-3026-5381)
- Deobrat Dixit (ORCID: https://orcid.org/0000-0003-4459-3904)
- D. Shan
- Tao Kang
- Zhen Jia (ORCID: https://orcid.org/0000-0003-3013-3886)
- Junxia Zhang (ORCID: https://orcid.org/0000-0001-7841-8675)
- Gaoyuan Cui
- C Li (ORCID: https://orcid.org/0000-0002-7223-4055)
- Qiankun Lin
- Jingshan Liang
- Danling Gu
- Xu Qian
- Kun Yang
- Kefan Song
- Fangshu Jin
- Wei Gao
- Zhu Zhu
- Hao You
- Hang Yu
- Weiwei Tao
- Zhe Zhu
- Fan Lin
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Iowa (US)
- University of Science and Technology of China (CN)
- Hefei University of Technology (CN)
- Huazhong Agricultural University (CN)
- Columbia University Irving Medical Center (US)
- Nanjing Health and Health Commission (CN)
- Zhongda Hospital Southeast University (CN)
- Jiangsu Cancer Hospital (CN)
- The First People’s Hospital of Lianyungang (CN)
- Model Animal Research Center (CN)
- Second Affiliated Hospital of Nanjing Medical University (CN)
- Changzhou No.2 People's Hospital (CN)
- Changzhou Third People's Hospital (CN)
- Huazhong University of Science and Technology (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2026-01-22
- DOI
- https://doi.org/10.1093/neuonc/noag015
- Primary Topic
- Bioactive Compounds and Antitumor Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00