Functional autoantibodies and coronary microvascular obstruction in STEMI: a translational link between immune mechanisms and prognostic outcomes
Agonistic autoantibodies against AT1R and ETAR directly damage coronary microvascular endothelium and reproduce key features of CMVO observed in STEMI patients. These findings support a clinically relevant, immune-mediated mechanism of microvascular injury and suggest that receptor antagonism represents a biologically plausible, receptor-dependent mechanism warranting further investigation as a potential microvascular protective strategy in high-risk STEMI patients.
Authors
- Francesco Tona (ORCID: https://orcid.org/0000-0003-4828-7875)
- Giovanni Civieri (ORCID: https://orcid.org/0000-0002-3076-4787)
- Donatella Tansella (ORCID: https://orcid.org/0009-0005-9684-6426)
- Marta Vadori (ORCID: https://orcid.org/0000-0002-9763-2383)
- Laura Iop (ORCID: https://orcid.org/0000-0002-7034-9414)
- Marika Martini (ORCID: https://orcid.org/0009-0000-0522-8408)
- Emanuele Cozzi
- Giulia Masiero
- Nicola Meynardi
- Nicola Morat
- Sabino Iliceto
- Giacomo Bernava
Institutions
- University of Padua (IT)
- Mater Dei Hospital (MT)
- LUM Jean Monnet University (IT)
- Mater Dei Hospital (BR)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2026-02-25
- DOI
- https://doi.org/10.3389/fcvm.2026.1739236
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Padova