Early outcomes from a new multidisciplinary cardiometabolic clinic: real‐world experience in lowering low‐density lipoprotein cholesterol

This study presents real-world data on low-density lipoprotein cholesterol (LDL-C) management in the first 200 patients seen at a new multidisciplinary cardiometabolic clinic from January 2023, with follow-up until April 2024. The cohort had a mean ± standard deviation age of 52 ± 14 years, 51% were male, 69 (35%) had familial hypercholesterolaemia and 66 (33%) had cardiovascular disease. Lipid-lowering therapies were escalated in 120 (60%) patients. Median low-density lipoprotein cholesterol level decreased with initiation of evolocumab (69%), inclisiran (56%), statin (45%) and ezetimibe (21%). In patients with a history of statin intolerance, 19 (43%) re-initiated or increased statin dose.

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Publication Details

Journal
Internal Medicine Journal
Published
2026-02-24
DOI
https://doi.org/10.1111/imj.70334
Primary Topic
Lipoproteins and Cardiovascular Health
Type
article
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article

Early outcomes from a new multidisciplinary cardiometabolic clinic: real‐world experience in lowering low‐density lipoprotein cholesterol

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article

Early outcomes from a new multidisciplinary cardiometabolic clinic: real‐world experience in lowering low‐density lipoprotein cholesterol

Krishnamurthy Chikkaveerappa, Bu B. Yeap, Girish Dwivedi, Ying Yi Wendy Yap, Nick S R Lan, P Gerry Fegan
article en

Abstract

This study presents real-world data on low-density lipoprotein cholesterol (LDL-C) management in the first 200 patients seen at a new multidisciplinary cardiometabolic clinic from January 2023, with follow-up until April 2024. The cohort had a mean ± standard deviation age of 52 ± 14 years, 51% were male, 69 (35%) had familial hypercholesterolaemia and 66 (33%) had cardiovascular disease. Lipid-lowering therapies were escalated in 120 (60%) patients. Median low-density lipoprotein cholesterol level decreased with initiation of evolocumab (69%), inclisiran (56%), statin (45%) and ezetimibe (21%). In patients with a history of statin intolerance, 19 (43%) re-initiated or increased statin dose.

Internal Medicine JournalVol. 56(3)
The University of Western Australia (AU), Victor Chang Cardiac Research Institute (AU), Curtin University (AU), Harry Perkins Institute of Medical Research (AU), Fiona Stanley Hospital (AU)
Good health and well-being
Openalex Percentile: Top 43%
Lipoproteins and Cardiovascular Health
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