Effect of modulation of alimentary and formulation pH on the pharmacokinetics of BCS-Class I, II, III, and IV compounds in rats following cassette dosing

The results suggest that both alimentary canal conditions with acidic and basic pH and formulation with acidic and basic pH have a considerable influence on the PKs of different compounds not only based on their acid dissociation constant (pKa) but also independently on the pH in the area of absorption in the alimentary canal and salt form of the compound.

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Publication Details

Journal
Drug Development and Industrial Pharmacy
Published
2026-03-04
DOI
https://doi.org/10.1080/03639045.2026.2635383
Primary Topic
Endodontics and Root Canal Treatments
Type
article
Field-Weighted Citation Impact
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article

Effect of modulation of alimentary and formulation pH on the pharmacokinetics of BCS-Class I, II, III, and IV compounds in rats following cassette dosing

Satinder Singh, Seema Gupta, Anroop B. Nair, Lakshmi Prasanna Tattala et al.
Drug Development and Industrial Pharmacy
Endodontics and Root Canal Treatments
article

Effect of modulation of alimentary and formulation pH on the pharmacokinetics of BCS-Class I, II, III, and IV compounds in rats following cassette dosing

Satinder Singh, Seema Gupta, Anroop B. Nair, Lakshmi Prasanna Tattala, Ravi Akkireddy, Satish Kumar, Sudhir Kumar Tiwari, Pratima Srivastava
article en

Abstract

The results suggest that both alimentary canal conditions with acidic and basic pH and formulation with acidic and basic pH have a considerable influence on the PKs of different compounds not only based on their acid dissociation constant (pKa) but also independently on the pH in the area of absorption in the alimentary canal and salt form of the compound.

Drug Development and Industrial Pharmacy
IDA Ireland (IE), King Faisal University (SA), GITAM University (IN)
Clean water and sanitation
Openalex Percentile: Top 44%
Endodontics and Root Canal Treatments
DOISourceOpenAlex
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Effect of modulation of alimentary and formulation pH on the pharmacokinetics of BCS-Class I, II, III, and IV compounds in rats following cassette dosing — Satinder Singh, Seema Gupta, et al. · Drug Development and Industrial Pharmacy (2026) | TGRS Research Map | TGRS