Can cell-based therapies bridge the gap between research and reality in the treatment of myocarditis? A systematic review and meta-analysis

Despite significant heterogeneity and moderate publication bias, the results were very encouraging, as reflected in the consistent effect directions across all studies in terms of cardiac function and histology. Overall, our results demonstrated the need for well-designed studies with adequate animal sample sizes, a standardized approach to reporting, and mechanistic investigations that directly link structural remodeling to functional recovery. Addressing these issues will be critical steps for conducting large-scale clinical trials.