Accelerated biological aging and the dynamic transitions of stroke and dementia: A multi-state trajectory analysis
BAA was associated with the initial onset of stroke, dementia, and mortality, whereas its associations with later progression to comorbidity were not evident. These findings suggest that BAA may be most informative for identifying early vulnerability, highlighting the potential value of targeting accelerated aging before clinical disease onset.
Authors
- Shuijing Zhang (ORCID: https://orcid.org/0000-0002-3929-5294)
- Pinfang Kang (ORCID: https://orcid.org/0000-0003-0556-1088)
- Wenke Cheng
- Yuli Huang
- Bi Tang
- Guangji Zhang
- Zhongyan Du
- Liuyu Chen
Institutions
- Zhejiang Chinese Medical University (CN)
- Bengbu Medical College (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1016/j.nbd.2026.107332
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00