Effects of 6-months of SSRI use on DNA-methylation and gene expression in blood

Medium-term SSRI use during the STEP trial was associated with changes in DNA-methylation that may partially explain the potential antidepressant mechanisms and adverse effects of SSRIs, however replication in other cohorts is necessary to establish if these changes are generalisable to SSRI use more broadly.

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Publication Details

Journal
Brain Behavior and Immunity
Published
2026-02-25
DOI
https://doi.org/10.1016/j.bbi.2026.106520
Primary Topic
Stress Responses and Cortisol
Type
article
Field-Weighted Citation Impact
0.00
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Effects of 6-months of SSRI use on DNA-methylation and gene expression in blood

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Effects of 6-months of SSRI use on DNA-methylation and gene expression in blood

Rebekah Street, Ella Davyson, Leanne Wallace, Naomi R. Wray, Enda M. Byrne, Jessica Spark, G.Paul Amminger, Tian Lin, Lauren F. Barker, Patrick D McGorry, Hok Pan Yuen, Allan F McRae, Barnaby Nelson, Anjali K Henders
article en

Abstract

Medium-term SSRI use during the STEP trial was associated with changes in DNA-methylation that may partially explain the potential antidepressant mechanisms and adverse effects of SSRIs, however replication in other cohorts is necessary to establish if these changes are generalisable to SSRI use more broadly.

Brain Behavior and ImmunityVol. 135
The University of Queensland (AU), Edinburgh Cancer Research (GB), Orygen Youth Health (AU), Orygen (AU)
Zero hunger
Openalex Percentile: Top 40%
Stress Responses and Cortisol
DOIOpen Access PDFOpenAlex
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