The anxious bipolar phenotype: clinical complexity and treatment response
Individuals with BD + ANX represent a more severely affected subgroup with distinct prescribing patterns favoring antidepressants over mood stabilizers and attenuated response to mood stabilizers. These findings highlight the need for anxiety-informed treatment algorithms recognizing anxiety comorbidity as a negative prognostic factor.
Authors
- David J. Bond (ORCID: https://orcid.org/0000-0002-8713-7311)
- Marin Veldić (ORCID: https://orcid.org/0000-0002-7651-9197)
- Ada Man-Choi Ho
- Richard Pendegraft
- Francisco Romo-Nava
- Manuel Gardea-Reséndez
- Brandon J. Coombes
- Balwinder Singh
- Alfredo B. Cuellar-Barboza
- Mark A. Frye
- Joanna M. Biernacka
- Susan L. McElroy
- Miguel L. Prieto
Institutions
- Mayo Clinic (US)
- Johns Hopkins University (US)
- Universidad Autónoma de Nuevo León (MX)
- Universidad de Los Andes, Chile (CL)
- Lindner Center of HOPE (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- International Journal of Bipolar Disorders
- Published
- 2026-02-26
- DOI
- https://doi.org/10.1186/s40345-026-00415-z
- Primary Topic
- Bipolar Disorder and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00