An Integrated Genotyping Strategy for α/β‐Thalassemia: Based on the Analysis of the Coding Sequences and Expression Levels of <scp> <i>HBA2</i> </scp> , <scp> <i>HBA1</i> </scp> , and <scp> <i>HBB</i> </scp> in Peripheral Blood <scp>mRNA</scp>
This mRNA-based strategy enabled detection of coding-region mutations in the HBA2/HBA1/HBB and prediction of non-coding-region mutations as well as gross deletions with high coverage, low cost and simple operation.
Authors
- Qi Yao
- Hongjian Chen
- Mianai Fu
Institutions
- Hainan Maternal and Child Health Hospital (CN)
Publication Details
- Journal
- Journal of Clinical Laboratory Analysis
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1002/jcla.70186
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00