Multi‐omic profiling reveals immune cell priming signature linked to lupus prognosis
Together, these results reveal parallel immune mechanisms in SLE and provide a framework to identify new therapeutic targets. Clinical and immune data are available for public exploration through an interactive SLE Immune Atlas.
Authors
- Sarthak Gupta (ORCID: https://orcid.org/0000-0001-8255-3554)
- Chia-Chien Chiang (ORCID: https://orcid.org/0000-0002-2110-8278)
- Carlos Roca
- Mariana J. Kaplan (ORCID: https://orcid.org/0000-0003-2968-0815)
- Jill Hénault
- Kamelia Zerrouki
- Richard M. Siegel (ORCID: https://orcid.org/0000-0001-5953-9893)
- Christopher J. Groves (ORCID: https://orcid.org/0000-0002-2386-4827)
- Melissa de los Reyes (ORCID: https://orcid.org/0000-0002-6055-0413)
- Rebecca Filippi
- Jun Chu
- Kerry Casey
- Michael A. Smith (ORCID: https://orcid.org/0000-0002-2191-5475)
- Anna M. Hansen (ORCID: https://orcid.org/0000-0002-1192-9435)
- Roland Kolbeck
- Saifur Rahman
- Zerai Manna
- Miguel A Sanjuan
- Michael Davis
- Rachel Ettinger
- Shu Wang
- Dominic Sinibaldi
Institutions
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (US)
- AstraZeneca (Australia) (AU)
- AstraZeneca (Singapore) (SG)
- AstraZeneca (Brazil) (BR)
- AstraZeneca (Japan) (JP)
- AstraZeneca (Canada) (CA)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1002/art.70105
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00