A Monoclonal Antibody ELISA–Based Assay for Measuring the Potency of Candidate H5 Clade 2.3.4.4b Pandemic Influenza Vaccines
The results demonstrated that the ELISA potency assay is suitable for determining the potency of inactivated H5 A/Astrakhan/3212/2020 influenza vaccines. Moreover, the results demonstrate the importance of preparing libraries of antibody reagents for influenza subtypes with pandemic potential so that suitable mAbs are available for development of alternative mAb vaccine potency assays when needed.
Authors
- Jerry P. Weir (ORCID: https://orcid.org/0000-0002-0260-0996)
- Falko Schmeisser
- Jackeline Soto
- Marcus Odin
Institutions
- Center for Biologics Evaluation and Research (US)
Publication Details
- Journal
- Influenza and Other Respiratory Viruses
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1111/irv.70206
- Primary Topic
- Influenza Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Health and Human Services
- Oak Ridge Institute for Science and Education
- Biomedical Advanced Research and Development Authority