glorund functions in the Drosophila intestine to regulate triglyceride storage and the expression of lipid transport protein genes

The intestine acts as the primary site for absorption of dietary lipids. These lipids are packaged and transported via lipoprotein complexes, whose altered levels correlate with metabolic disease. &nbsp;The <i>Drosophila</i> splicing factor glorund (glo) has been shown to affect the expression of apoB-family lipoproteins, including microsomal triacylglycerol transfer protein, lipid transfer particle, and lipophorin, in the fly adipose tissue. Here, we demonstrate that decreasing <i>glo</i> in intestines leads to increased whole animal triglyceride storage, but decreased expression of lipid transport protein genes. Together, these data suggest that glo functions in the intestine to regulate lipid transport and organismal fat storage.