Sestrin2 inhibits ferroptosis to alleviate hypertension via AMPK/Nrf2/GPX4 axis activation

Sestrin2 inhibits ferroptosis to prevent hypertension by activating the AMPK/Nrf2/GPX4 pathway, suggesting its potential as a therapeutic target for hypertension.

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Publication Details

Journal
European journal of medical research
Published
2026-02-25
DOI
https://doi.org/10.1186/s40001-026-04090-9
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00
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article

Sestrin2 inhibits ferroptosis to alleviate hypertension via AMPK/Nrf2/GPX4 axis activation

Yuan Li, Jie Qi, Fengchao Wu, Ju Yan et al.
European journal of medical research
Ferroptosis and cancer prognosis
article

Sestrin2 inhibits ferroptosis to alleviate hypertension via AMPK/Nrf2/GPX4 axis activation

Yuan Li, Jie Qi, Fengchao Wu, Ju Yan, Yongyong Zhao, Yaozhang Guo, Haoyu Wu
article en

Abstract

Sestrin2 inhibits ferroptosis to prevent hypertension by activating the AMPK/Nrf2/GPX4 pathway, suggesting its potential as a therapeutic target for hypertension.

European journal of medical research
Shanxi Medical University (CN), Xi'an Honghui Hospital (CN), Shanxi Provincial People’s Hospital (CN)
Zero hunger
Openalex Percentile: Top 43%
Ferroptosis and cancer prognosis
DOIOpen Access PDFOpenAlex
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