The Age at Onset of <scp>LRRK2</scp> p. <scp>Gly2019Ser</scp> Parkinson's Disease Across Ancestries and Countries of Origin
Our results provide evidence that a person's genetic ancestry and country of origin are associated with the AAO of LRRK2-PD. This highlights the potential impact of both genetic and environmental factors on LRRK2-PD AAO. ANN NEUROL 2026.
Authors
- Theresa Lüth (ORCID: https://orcid.org/0000-0003-0458-0498)
- Sebastian Sendel (ORCID: https://orcid.org/0000-0002-1635-4247)
- F. Hentati
- Inke R. Koenig
- Joanne Trinh
- Björn-Hergen Laabs
- Amke Caliebe
- Rim Amouri
- Samia Ben Sassi
- Soraya Bardien
- Christine Klein
- Matthew Farrer
- Laurel A Screven
- Alastair J Noyce
- Global Parkinson's Genetics Program (GP2)
Institutions
- South African Medical Research Council (ZA)
- Queen Mary University of London (GB)
- University of Erfurt (DE)
- Stellenbosch University (ZA)
- University of Florida Health (US)
- Tunisia Private University (TN)
- University of Florida (US)
- University Hospital Schleswig-Holstein (DE)
- Universitätsmedizin Göttingen (DE)
- National Institute on Aging (US)
- Institut National de Santé Publique (TN)
- National Institute of Neurology Mongi-Ben Hamida (TN)
- University of Lübeck (DE)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1002/ana.78181
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00