Radical-Mediated Methylenation of <i>N</i> -Heterocyclic Carboxylic Acids with DMSO to Access Exocyclic Olefinic Azacycles
A radical-mediated methylenation of <i>N</i>-heterocyclic carboxylic acids with DMSO is developed using KF as a catalyst, which allows efficient access to exocyclic olefinic azacycles. This novel strategy features transition metal-free conditions, the direct use of DMSO as a methylene source, and a free-radical cascade process.
Authors
- Kaiping Hou
- Lishou Yang
- T Deng
- Lanfeng He
- Enhua Wang
- Xiaosheng Yang (ORCID: https://orcid.org/0000-0003-1535-3282)
- Lang Zhou
- Linlin Dai
- Xiong Pan
Institutions
- Guiyang Medical University (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Agriculture and Food (AU)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1021/acs.joc.5c03092
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00