Convergent genomic and molecular features predict risk of metachronous metastasis in clear cell renal cell carcinoma
Overall, our study highlights convergent genomic and transcriptomic alterations in chromosome 1p, driving dysregulation of epithelial cell polarity and fatty acid metabolism, as putative risk factors of metachronous metastasis in ccRCC.
Authors
- Renzo G. DiNatale (ORCID: https://orcid.org/0000-0002-7867-2881)
- Marjan M. Naeini
- Neha Rohatgi (ORCID: https://orcid.org/0000-0003-1103-0259)
- Umesh Ghoshdastider (ORCID: https://orcid.org/0000-0003-4471-9394)
- A. Skanderup (ORCID: https://orcid.org/0000-0001-6847-4980)
- Mengyuan Pang (ORCID: https://orcid.org/0000-0002-2503-7550)
- A. Ari Hakimi
- Sinem Kadioglu
- Roy Mano
Institutions
- Agency for Science, Technology and Research (SG)
- Memorial Sloan Kettering Cancer Center (US)
- Garvan Institute of Medical Research (AU)
- St Vincent's Clinic (AU)
- Genome Institute of Singapore (SG)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1038/s43856-026-01436-6
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00