Outcomes of heart failure with reduced, mildly reduced, or preserved ejection fraction: the ESC HF III registry

In HF in Europe and affiliated countries, in-hospital mortality was 5.1% and greater with lower ejection fraction. Among hospital survivors and out-patients over 1 year of follow-up, event rates per 100 patient-years varied for death, 3.9-22, CV death 1.7-13, and unknown cause of death 0.8-6.3. The percent of patients that were (re-)hospitalized for HF at least once over 1-year follow-up ranged 14-44% and was twice as high post-AHF compared with post-out-patient visit.

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Journal
European Heart Journal
Published
2025-12-17
DOI
https://doi.org/10.1093/eurheartj/ehaf1074
Citations
1
Primary Topic
Heart Failure Treatment and Management
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article
Field-Weighted Citation Impact
1.39

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article

Outcomes of heart failure with reduced, mildly reduced, or preserved ejection fraction: the ESC HF III registry

M. Crespo-Leiro, Duška Glavaš, Israel Gotsman, Gianluigi Savarese et al.
1 citations
European Heart Journal
Heart Failure Treatment and Management
1.39
article

Outcomes of heart failure with reduced, mildly reduced, or preserved ejection fraction: the ESC HF III registry

M. Crespo-Leiro, Duška Glavaš, Israel Gotsman, Gianluigi Savarese, Mitja J. Lainscak, Ahmed Bennis, Grigorios Giamouzis, Eleonora Vataman, A. Simms, Marek Gierlotka, J.-L. Georges, Gulnaz Dadashova, Lucica Grigorică, Wachter Rolf, Tiina Uuetoa, A-P Petronio, Vassilis I. Barberis, JM. Tartiere, Rudolf Berger, José Manuel García Pinilla, STEFAN STOERK, L-L Buttigieg, A.-C. Pouleur, Barnabas Gellen, Micha T. Maeder, Hadi Skouri, G Filippatos, L H L Lund, M L Mitja Lainscak, A Brkic, A Salzano, M H Abdelnabi, A Elkeurti, M Metra, H Tolppanen, M Baldassi, M Proenca, Laurent Fauchier, O Havakuk, C Genin, J Simic, S Amorim, M Koenig, B Beleslin, I Yakupova, A Avdic, R Lucci, K Drazek, A Boudrifa, D Bilyi, M Glikson, M Sitnikova, A. Sousa, A Lachhab, Petra Van Pol, C Casset, A Smolarczyk, G Benhayoune, E Samohvalov, F El Harrane, J Szponar, C Militaru, C Saint Andre, A Kosztin, M Dweck, M Kiedrowska, P Blanco Canosa, T Rodrigues, A Nurmukhambetova, G Parati, N Nyolczas, M Lelonek, O Basaran, M Vucijak Grgurevic, V Batushkin, F Mgazeel, A Cichocka-Radwan, E Barge Caballero, M Abdelhamid, B Mena, I Senesael, E Mirrakhimov, Milos Taborsky, M Maciejewski, E Stimjanin, V Barberis, S Miseljic, S Kakoulli, C Holt Bendz, L Michalis, B Veermäe, B Todurov, I S Benedek, F Ramani, P Redondo-Gomez, O Yarynkina, E Becirovic, J Silva-Cardoso, L Fauchier, A Biscevic-Obradovic, A Gray, R Pancheva, Alanya A Coner, S Abderrazak, D Simonovic, A Stepura, L Sebbag, I Kurbasic, O Friberg, J A Borovac, M Kuznetsova, A Iosip, M Maurin, N Cmor, K Mizia-Stec, L Talbi, United M Aldwaik, V Sovtus, N Pezzutto, A Karakiyan, A Kozyrava, J Borkyte, M Dogot, M Abdel Ghany, N Dovganych, I Nordkin, A Nedoshivin, M Szabo, R. Pinto, S James, C Brízido, C Calloni, K Azaryan, J Lewek, N Djefel, M Pyziak Stepien, D Toncev, Andrew Coats, L Lysgaard Gullestad, M Driussi, M Rabai, I Mitevska Peovska, C Chalard, K V Nagy, E-O Akpan, R J Gil, P Agostoni, N Elouafi, A Gackowski, D Mackic, A El Bagoury, E Plan, C Bergerot, G Savarese, D Bosnjakovic, O Geavlete, C Dericbourg, T Osman, N Hrynchyshyn, S Kovacsne Levang, S Paolillo, Y Sim, G Sofiane, A Sourat, V Aleksandrenko, V Ivan, S Ztot, M Braga, B Sadeh, I Hudic, D Budzynski, I Orlova, B Meder, R Norvilaite, S Essadki, V Skibitskiy, M Salvat, A Pálinkás, I Dimou, S Sadon, A I Perez Cabeza, C Corciova, B Leskovar, K Aganovic, A Swiatkowski, H Lachhab, O Zid, D C Ciuculete, Y U Celikyurt, P Cloitre, W Takdemt, P Janeira, F Djelaili, A Cieslak, O Kolomatskaya, C Cruzado Alvarez, M Szulik, V Kolev, Daniela Cassar Demarco, A Camacho, E Ottenblad, O Markova, Y Sellah, E Barreira, M De Stefano, M Rybak, A L P Caforio, E G Pascu, Plamen Gatzov, S Maltes, M Pytliak, A E Atas, J Wieczorek, A Abdeltawab, V Kaplunova, N Aidargaliyeva, O Shatova, I Grech, L Pojskic, R. Pilato, S Pepoyan, O Prytuliak, L Lakkas, S Benkhedda, J Urbanowski, S. Braun, J Agostinho, M F Areed, L Antohi, M T Bailly, A-S M Sabry, B A Popescu, H Torlak, O Ezra, M Stojanovic, D Karacimen, P Fournier, F Ruschitzka, A Gardin, P Araújo, G Hogalmen, Eva Prescott, L Tunyan, T Anier, Z Benchaouia, C Charbonnel, Andrejs Erglis, M S Komissarova, M Rembek Wieliczko, A Shchendrygina, H Morillas Climent, R Bekbulatova, H Altay, O Akkus, O Khaniukov, N Botnari, A Mallardi, A Vogrincic Cernezel, Ö Yildirimtürk, O Gurne, A Roshdy, G Elmazani, B Gellen, V A Lazarev, I Bijedic, M Tadevosyan, E Ramic, P Jourdain, R Salgado, R Itier, E Paleviciute, O Berezin, R G Xuereb, A Robles Mezcua, A Brkovic, R Halmosi, K Bula, M Tuce, A Honcharuk, M German, N Borsic, S Cudini, C Miotti, Amina Rakisheva, E Velaoras, I Drapchak, A Mujakovic, M Magnocavallo, F Weidinger, B Cebulak, S Romano, R D´assante, M Barisic, E Jahic, U Zeymer, A Sergeeva, A Bounah, F El Idrani, D Tagaeva, S Veljkovic, D Malmendier, E Zanelli, P Karavaev, M Kayikcioglu, A Kamal, Bela Merkely, T Habon, M Dolzhenko, M Ghita, H Acet, K Rudenko, L Tumasyan, M Kharoubi, Eva Goncalvesova, M-A Bazbani, E Zheleznykh, M Abdelghany, P Troisfontaines, A Begic, J Presume, R Petroni, Petar M Seferović, A Parkhomenko, A Sayah, A R El Sayed, Magdy Abdelhamid, C Stanescu, S Akinci, P Leszek, K Oksaharju, R Myasnikov, S Poznic, O Vasylenko, O Botrous, M Deljanin Ilic, N Sishkina, Z Kalarus, V Gardan, A Z Baños Velasco, N Dahimene, B Rocha, Candida Fonseca, A Stepanyan, Y Danilogorskaya, J Fleri Soler, G C Moise, T Fourme, A Bechlioulis, Y Antoniuk, Ovidiu Chioncel, M Dupont, S Soulami, D Lecuyer, M M Yousif, N Dagres, D Simic, L Bouzoubaa, G Skonieczny, T Furlan, Z Galeeva, A Monfort, J Pavic Poljak, M J Paniagua Martin, C Riveiro Rodriguez, F Grossi, S Leon Gonzalez, Z Ismagulova, D Bodez, M Amin, M Massoz, O Medentseva, T Simbelyte, D Adlam, E Bjorkelund, I Lupasteanu, N Oprescu, V Zektser, Massimo Francesco Piepoli, G Cunha, S Sokolovic, D Guijarro, J Emberson, Z Kobalava, C Delcea, E Zorina, S Mirzarakhimova, M Eshak, A Bijedic, L Dizdarevic-Hudic, S Hajib, M Gasiorowski, K Sosinska, N Mironova, D Salauyou, F Kerkouri, W Camilleri, M Gierlotka, K Neronova, N Samoila, E Shavarova, A Rasulov, M J Fernandez Anguita, C Hage, M Vella, M Bensaoud, M Tesic, S Xuereb, Gani Bajraktari, A Denizet Mulocher, V Stoyanovski, A Rakisheva, A Hbali, S Essam, T Simagina, M Hovhannisyan, F Sabatino, H Elnesr, A P Maggioni, T Christodoulides, V Tseluyko, C Ortiz Cortés, D Ziecik, P Armangau, D Wexler, D Duplyakov, M Zdravkovic, R Bonnici, I Rudyk, T Popov, B Moura, M Dorobantu, P Chrusciel, J Begrambekova, N El-Jonhy, V Garvey, S Cemerlic Maksimovic, A Makhmudova, N Danchin, T Uuetoa, A Saad, M Kozhevnikova, A Valle Muñoz, M Fonseca, A Bobel, A Grivenco, C P Gale, G Sinagra, A Mazutaviciute, A H Eladawy, K Vrbinc Vrtek, H Hasan-Ali, S Abdelali, C Karvounis, A M Marra, B Kilicaslan, J Esenbekova, R Benkouar, M Polovina, A Moustaghfir, Artan Goda, Julinda Mehilli, D Loncar, A. Moya, E Tshilanda, A El Makhlouf, M K Shokry, F Yavuz, A Selimagic, D Derthoo, A Kujawa, O Lairez, V Larina, O Zharinov, R Manley, D Balta, F Kadic, D Sacic, AvTimoteo, A Dolacinska, D Bursacovschi, A Olivares, S López Fernández, J Roncalli, J-F Laine, F Challal, D-E Nibouche, A Tleules, C Attard, L Gedvilaite, M Halilcevic, B Azeredo, I Ilgisonis, Z Kušljugic, Y Lididi, S Šaric, P António, M Melissopoulou, G Nurbekova, Y Tir, V Servaes, I Cojuhari, E V Resnik, D Lisii, R Chernitsov, A Kassenova, E I Yuce, R Hodas, T Levinas, Cassano Delle A Passantino, M Merlo, E Salvioni, M Ašanin, A Kuular, N Wiligorska, Nizhny N Vinogradova, A Giuca, R Tuleutayev, A Torbica, R. ; https://orcid.org/0000-0003-2258-3262 Fernandes, P Marquez Camas, R Santos, M Hosny, C Bouleti, V Dinraths, I N Karavidas, R Muradyan, G Patti, T Abdullaev, S Naessens, M Wawrzacz, A Frisinghelli, E Kudryashova, J Celutkiene, M Penco, C Rodrigues, S Oghina, S Christiaens, O Irkin, Giuseppe Rosano, Elizabeta Srbinovska Kostovska, F Alhussein, R Iznatova, M Buisson, A Fendrikova, B Demirkan, M Pietila, E Privalova, K Adnan, D Zaliaduonyte, H Elnaajer, V Martinez Mateo, E Cierpiala, A Bikiewicz, C Biendel, B Stoimenov, D Bogdanovic, J Simonavicius, L Salgado, E Hodzic, K Krupychka, G Martirosyan, C-J Sinescu, I Araujo, A Klaus, P Solik, A Dzubur, A El Ouazzani, I Tsoy, S M Shaheen, L Jordán Martínez, N Cunha, D Mrozowska, A I Kovaleva, J Cazacu, E Berthelot, I Rudenko, I Ukpeh, T Michaelidou, G Terrien, A Tralhão, A Subo, A Sik, S Maier, V Grilj, N Baron, F M Vizcaíno Rios, G Buhagiar, B Matrone, O Dovhan, N Avram, Stefan Anker, R Buzas, Erkin Mirrakhimov, P Morais, P Gugliandolo, I Vakaliuk, S Jacquet, P P S Selwanos, A Jobbé Duval, K Kopeva, A Scafa Udriste, Y Arbel, E Begic, H Selimovic, D Cravo, J-C Amirault, J-B Azowa, M Tokmakova, Lars Lysgaard Gullestad, D Brito, L Morcillo Hidalgo, M Mancone, Aldo P Maggioni, Yuksel Cavusoglu, M Trukshina, S Chraibi, D Simeunovic, N Blagojevic, M Gilard, S Pereira, E Tebbache, C Guizar, C Tavares Aguiar, C Augier, I Couri, B Ivanovic, M Idjellidaine, N Cetin, L Sahakyan, B Unal, E Sels, I Alla, N Runev, K Pirog, I Petrovic Djordjevic, F J Rossello, Marco Metra, S Goliszek, J Inamo, N Hammoudi, O Kremzer, M Režun, J Stevic, V Babayan, Walter Droogne, G Novo, G Abidi, E Smajic, P Poret, A. 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Silva, Julien Magne, R Bouhouch, M Galinier, D Cassar Demarco, J Djelmic, T Friscic, O Chioncel, L Sursaieva, L Chami, M O De Los Rios Ibarra, R Basake, M Demir, C Altin, the ESC EORP HF III National Leaders and Investigators, J Dejanovic, I Aguiar Ricardo, M Piskareva, A Mendez, C Cadeddu Dessalvi, M Pietraszek, S Lenaerts, G Mamedova, K Andjelkovic, K Ozieranski, D Jovanovska, Frank Ruschitzka, S Kozhuhov, Sremska I Srdanovic, A Wittczak, A Nunes-Ferreira, M Ostojic, A Halim, B E El Younassi, S Hinic, D G Baltag, A Garkusha, I Veljic, D Erlinge, J Seller Moya, C. Fonseca, J Latek, D Adorno, M Kovacevic, M Selimovic, V Gavrina, V Mincheva, P M Seferovic, N Thor, F Severino, F O Arican Ozluk, H Sisakian, M Hassan, R La Gioia, Tina Hansen, E Babayigit, G Halasz, V Tsanova, L Moderato, F Custovic, N Hadžibegic, L Hrubyak, A Metzgier Gumiela, A M Moore, J Rossello, C Naya Leira, A Ventosa, A Agacdiken Agir, A Dokovic, U Kamilova, Timur Abdullaev, S Benyamin, A Kaplon-Cieslicka, Dulce A Brito, M Dumoulein, D Djermane, E Bulgakova, M Cicoira, S Darnés Soler, L Illes, M Lia, M Alkenova, F Beauvais, E Salustri, A Siniarski, I Lischuk, A Surminova, S Wisniowska-Smialek, A Ilic, T Lelyavina, A Nazaruk, I Milinkovic, O Bazyka, E Radzishevsky, N Rat, H Kandil, B Iung, F Pawliczak, A Chilingaryan, S Viks, S Rostásné Toth, A G Mahmoud, V Fesenko, S Bari, Z Gljiva Gogic, Alexandre Mebazaa, J W Roos-Hesselink, F L Ribichini, P Bojcík, A Djozic, G Heyndrickx, G Ganci, Krivoy V Potabashniy, A Zakaria, A Karimov, A Cittadini, B Menebhi, F Bermúdez Jiménez, V D’Onofrio, A-S Petronio, V Delgado, M Bouame, M Wozniak, N Bennacer, I Zakharova, O Drapkina, I Cabac-Pogorevici, E Smirnova, N Sabanovic Bajramovic, S Milutinovic, S Minardi, Mikheil Tsverava, Z Sokaeva, E Andreenko, A Galyavich, M Danko, E Bonni, D Urazbekov, N Maniadakis, M F Piepoli, G Baudry, D Logeart, L. 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Sahin, D Mohamed-Said, R Mesbahi, H Costa, R Gal, G Krljanac, A Louali, A Rodriguez Cordoba, T Farrugia, A Yusupova, T Kukulski, S Scalvini, Leonid Voronkov, S Guendouz, Niska B Ilic, R Kurbanova, J Laukaitiene, A Peccianti, B Merkely, D Wiligorska, D Babichev, A Celik, I Asfalou, O Mbang, A Ferlisi, L Lobach, I F Yaseen, V Revenco, I Budanova, Z Grille Cancela, L H Lund, M Kleszczewska, D Ghellab, D Raljevic, A Rammos, M Milli, A Cohen-Solal, D Djikic, T Petrusheva, K Bennis, A Kamel, K Kovacevic, V Pelizzoni, A Akanova, N Spiropulos, P Perrone-Filardi, E Pagliaroli, M Rolirad, A Drissi Kacemi, O Fronea Gheorghe, E Szogi, M Setti, M Radovanovic, I Popov, E Srbinovska Kostovska, D Lighezan, S Benferhat, E Straburzynska-Migaj, Y Belenkov, J Plonka, M Mintchev, L Grib, A Bennis, D Milicic, I Juhasz Nagy, E Hoffer, S Bouzidi Belmajdoub, O Sakarya, O Kulikova, E Garau, T Manukyan, C Burak, M Sut, H Ali Farhan, V Popadic, A Sutkowska, N Ozier-Lafontaine, C Bachelet, A Pawlak, D. Matic, T Zaninovic Jurjevic, E Goncalvesova, J Djokic, S Klasnja, X Resende, S Dimitry, A Melekhov, A Karabinowska, Z Planinic, T Pavlunina, T Durat, O Kniazieva, D Vagany, M Sammak, S Nurlybai, M Akilbekova, G Gendlin, N Matviichuk, F Granstrom, L Majc Hodoscek, L Resendiz-Barron, G Barge Caballero, O Haugene, A Garganeeva, Y A Abdelhady Ahmed, I Pashkova, D Neglia, I Gruev, Tel M Laufer-Perel, A C Florea, I Juhasz, Baia C Pop, E Prescott, J Brito, M Najat, M Banach, K Mouzaoui, A Bielecka-Dabrowa, Vyacheslav Mareev, D Stefanovic, J L Bonilla Palomas, I Nassiri, F Daimellah, E Jonsson, H Batjoens, V Drljavic, A Karavidas, E Dzambasovic-Karaselimovic, C Bros, L Restivo, M. Dudek, R Buhagiar, D Mršic, K Pesek, A Vijan, C Delmas, S Roginic, B Livarek, P Leczycki, A Samir, Zielona P Jesionowski, T Zemleduch, M Raissouni, J Hausleiter, E Dora, K Rekucki, S Udalova, E Sener, E Lefebvre, H Ammar, Targu T Benedek, M Vanderheyden, J Nessler, F Fellini, T Pilgrim, M Nygren, A Galat, M Kopytsya, E Emmanuel, Theresa A McDonagh, T Damy
article en
1 citations

Abstract

In HF in Europe and affiliated countries, in-hospital mortality was 5.1% and greater with lower ejection fraction. Among hospital survivors and out-patients over 1 year of follow-up, event rates per 100 patient-years varied for death, 3.9-22, CV death 1.7-13, and unknown cause of death 0.8-6.3. The percent of patients that were (re-)hospitalized for HF at least once over 1-year follow-up ranged 14-44% and was twice as high post-AHF compared with post-out-patient visit.

European Heart Journal
Universidade da Coruña (ES), Serbian Academy of Sciences and Arts (RS), University of Lisbon (PT), University of Ljubljana (SI), Inserm (FR), Carol Davila University of Medicine and Pharmacy (RO), University of Zenica (BA), Università degli studi di Cassino e del Lazio Meridionale (IT), National and Kapodistrian University of Athens (GR), Université Paris Cité (FR), Karolinska Institutet (SE), San Raffaele University of Rome (IT), European Society of Cardiology (FR), "Dunarea de Jos" University of Galati (RO), Jerusalem Multidisciplinary College (IL), Hospital Universitário de Santa Maria (BR), Pomurski muzej Murska Sobota (SI), Associazione Nazionale Medici Cardiologi Ospedalieri (IT), Danubius International University (RO), IRCCS Policlinico San Donato (IT), University Hospital of Zurich (CH), Surgical Specialties (Canada) (CA), Hôpital Lariboisière (FR), Hôpitaux Universitaires Paris-Ouest (FR), Health Care Foundation (CA), German Centre for Cardiovascular Research (DE), Institute of Cardiology (PL), Hospital de Santa Maria (PT), King's College Hospital (GB), Instituto de Investigación Biomédica de A Coruña (ES), Yerevan State Medical University (AM), Charité - Universitätsmedizin Berlin (DE), University of Split (HR)
Amgen, Bristol-Myers Squibb, Pfizer, AstraZeneca, Bayer, Sanofi, Alnylam Pharmaceuticals, Edwards Lifesciences, Hamilton Health Sciences, Boston Scientific Corporation, Strong, Amarin Corporation, ZOLL Medical Corporation, Abiomed, Novo Nordisk, Universität Zürich, Servier, Innosuisse - Schweizerische Agentur für Innovationsförderung, MicroPort, Novartis Pharma, Abbott Vascular, Abbott Diagnostics, Daiichi Sankyo Europe
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Openalex Percentile: Top 12%
Heart Failure Treatment and Management
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