Sequenced treatment alternatives to relieve adolescent depression: A pragmatic clinical trial
In this study, fluoxetine combined with CBT showed no significant advantage over fluoxetine monotherapy. All strategies in step 2 were feasible and acceptable. Our findings supported the feasibility of th sequential treatment pathway for adolescent MDD and provided insights for future adequately powered trials.
Authors
- Xueer Liu
- Xuemei Li (ORCID: https://orcid.org/0009-0006-6021-0298)
- Xiaoxia Xu (ORCID: https://orcid.org/0009-0005-3699-235X)
- Yulin Wen
- Bingjie Qin
- Xiaocong Jiang
- Hongyi Cheng
- Yao Li
- Ting Wang
- Xinyu Zhou
- Yu Xian
- Teng Teng
- Yuqian He
- Tian Qiu
Institutions
- Dalian Medical University (CN)
- Second Affiliated Hospital of Chongqing Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1016/j.jad.2026.121511
- Primary Topic
- Child and Adolescent Psychosocial and Emotional Development
- Type
- article
- Field-Weighted Citation Impact
- 0.00