Initial Calcium Derangements in Major Trauma and Outcomes
In this cohort study of trauma patients, hypercalcemia was less common than hypocalcemia; however, hypercalcemia was associated with worse mortality at all time points. Blood product consumption was higher among those with hypercalcemia or hypocalcemia compared with eucalcemia but was similar among those with any calcium derangement. Prospective interventional trials are needed to understand the implications of empiric treatment.
Authors
- Stacy Shackelford (ORCID: https://orcid.org/0000-0003-3585-2150)
- Michael D. April (ORCID: https://orcid.org/0000-0001-5621-441X)
- Melody A. Martinez
- Franklin L. Wright (ORCID: https://orcid.org/0000-0002-4433-5385)
- Lauran Barry
- Andrew D Fisher (ORCID: https://orcid.org/0000-0003-1994-7774)
- Jennifer M. Gurney (ORCID: https://orcid.org/0000-0002-0451-1137)
- Allyson A. Araña (ORCID: https://orcid.org/0000-0003-4365-4656)
- Michael Adam Meledeo (ORCID: https://orcid.org/0000-0001-9958-9115)
- Isabel Gala Newton (ORCID: https://orcid.org/0009-0006-3203-1348)
- James A. Bynum (ORCID: https://orcid.org/0000-0003-1450-5221)
- Dayana Sifuentes
- Jessica Mendez
- Col Vikhyat Bebarta
- Susannah E. Nicholson
- Brian J. Kirkwood
- Andrew P. Cap
- R. Jimena Huaman
- Bethany C. Lambert
- Alex C. Cheng
- Julie A. Rizzo
- Fabiola Mancha
- Steven G. Schauer
- Donald H. Jenkins
- Brit J. Long
Institutions
- Uniformed Services University of the Health Sciences (US)
- The University of Texas at San Antonio Health Science Center (US)
- Defense Health Agency (US)
- Combat Medical (Spain) (ES)
- 59th Medical Wing (US)
- United States Army Institute of Surgical Research (US)
- University of Virginia Medical Center (US)
- United States Air Force Academy (US)
- The University of Texas at San Antonio (US)
- Vanderbilt University Medical Center (US)
- The University of Texas Health Science Center at Houston (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2026-02-25
- DOI
- https://doi.org/10.1001/jamanetworkopen.2026.0083
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00