WNT5A induces profibrotic activation of human macrophages via pSTAT3
Collectively, these results indicate that WNT5A mediates profibrotic macrophage activation through a pSTAT3-dependent mechanism. As SSc fibroblasts secrete elevated levels of WNT5A, our experiments suggest that in addition to autocrine functions, paracrine WNT5A may also contribute to pathological macrophage activation in SSc.
Authors
- Zhongle Liu (ORCID: https://orcid.org/0000-0003-4198-8214)
- Patricia Ann Pioli (ORCID: https://orcid.org/0000-0001-6896-7259)
- C. Y. Wang
- Rezvan Parvizi (ORCID: https://orcid.org/0000-0001-8650-1225)
- Emily A. Morris (ORCID: https://orcid.org/0009-0009-7002-6226)
- Chanhyuk Park (ORCID: https://orcid.org/0000-0002-6350-667X)
- Jonathan A. Garlick (ORCID: https://orcid.org/0000-0003-0607-0272)
Institutions
- Dartmouth College (US)
- Tufts University (US)
- Dartmouth Psychiatric Research Center (US)
Publication Details
- Journal
- Lara D. Veeken
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1093/rheumatology/keag104
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00