Based on single-cell and transcriptome analysis of inflammatory pathway biomarkers and their molecular mechanisms in chronic obstructive pulmonary disease

This study identified CXCL12, CXCR4, GGT1, and VWF as key genes in COPD pathogenesis. Macrophages constituted the only cell type exhibiting significant abundance alterations, with CXCR4 demonstrating persistent expression throughout macrophage differentiation trajectories. These findings provide valuable insights and suggest potential directions for developing precision therapeutic strategies for COPD.