RNA Polymerase III suppresses varicella zoster virus in human neurons
This work identifies a novel role for POLR3F as a sentinel for VZV reactivation in neuronal cells and lends further support to the hypothesis that POL III plays a role in immunity to VZV mainly upon reactivation in humans and that POL III defects predispose to VZV central nervous system infection.
Authors
- Madalina Elena Carter-Timofte (ORCID: https://orcid.org/0000-0002-1752-2820)
- B. Ritter
- Michelle M. Thomsen (ORCID: https://orcid.org/0000-0002-8437-8144)
- Jiayi Wang
- Trine H Mogensen
Institutions
- Qingdao University (CN)
- Aarhus University (DK)
- Aarhus University Hospital (DK)
- Medizinische Hochschule Hannover (DE)
- German Center for Infection Research (DE)
- Qingdao Municipal Hospital (CN)
- Institute of Virology of the Slovak Academy of Sciences (SK)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2026-02-24
- DOI
- https://doi.org/10.1093/infdis/jiag117
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00